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\u4eca\u56de\u306fJournal of Orthopedic Translation\u3088\u308a\u7b4b\u8089\u306e\u518d\u751f\u3068\u708e\u75c7\u306b\u3064\u3044\u3066\u306e\u30ec\u30d3\u30e5\u30fc\u3067\u3059\u3002<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

\u3053\u3061\u3089\u306e\u8ad6\u6587\u3092\u8aad\u307f\u3001\u53c2\u7167\u3057\u8a18\u4e8b\u3092\u66f8\u304d\u307e\u3059\u3002\u7b4b\u8089\u306e\u518d\u751f\u3068\u708e\u75c7\u306e\u95a2\u4fc2\u306b\u3064\u3044\u3066\u3067\u3059\u3002<\/p>\n\n\n\n

\u7b4b\u8089\u306f\u4f53\u91cd\u306e\u7d0440%\u7a0b\u5ea6\u3092\u5360\u3081\u307e\u3059\u3002<\/p>\n\n\n\n

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\u3053\u308c\u306f\u7b4b\u5f62\u8cea\u819c\u3068\u57fa\u5e95\u819c\u306e\u5b8c\u5168\u7684\u306a\u7834\u58ca\u304c\u3042\u308b\u3068\u3001\u7d30\u80de\u5916\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u6d41\u5165\u3092\u3082\u305f\u3089\u3057\u6700\u7d42\u7684\u306b\u7b4b\u8089\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5206\u89e3\u3068\u58ca\u6b7b\u3092\u5f15\u304d\u8d77\u3053\u3059\u306e\u3067\u3059\u3002<\/p>\n\n\n\n

\u6025\u6027\u708e\u75c7\u306e\u6d3b\u6027\u5316\u306e\u7d50\u679c\u3068\u3057\u3066\u7b4b\u8089\u306f\u5909\u6027\u3068\u816b\u8139\u3001\u8840\u816b\u306e\u5f62\u6210\u304c\u4fc3\u9032\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

\u6700\u521d\u306e\u7b4b\u8089\u5909\u6027\u306e\u5f8c\u3001\u7b4b\u8089\u5e79\u7d30\u80de\u306b\u3088\u3063\u3066\u5a92\u4ecb\u3055\u308c\u308b\u7b4b\u8089\u518d\u751f\u304c\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u306e\u3067\u3059\u3002<\/p>\n\n\n\n

\u8ca0\u50b7\u3057\u305f\u7b4b\u7dda\u7dad\u306f\u3001\u518d\u751f\u3057\u3001\u53ce\u7e2e\u529b\u3001\u65b0\u9673\u4ee3\u8b1d\u306a\u3069\u306e\u7b4b\u8089\u6a5f\u80fd\u3092\u56de\u5fa9\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n

\u7b4b\u8089\u5e79\u7d30\u80de\u306b\u3064\u3044\u3066<\/strong><\/p>\n\n\n\n

\u7b4b\u8089\u5e79\u7d30\u80de\uff08\u885b\u661f\u7d30\u80de\uff09\u306f\u7b4b\u8089\u306e\u518d\u751f\u306b\u5927\u304d\u304f\u95a2\u308f\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u3053\u308c\u3089\u306e\u7d30\u80de\u306f\u7b4b\u9798\u3068\u7b4b\u7dda\u7dad\u3092\u53d6\u308a\u5dfb\u304f\u57fa\u5e95\u819c\u306e\u9593\u306e\u819c\u3067\u56f2\u307e\u308c\u305f\u30cb\u30c3\u30c1\u3068\u3044\u3046\u90e8\u5206\u306b\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u904b\u52d5\u3001\u5916\u50b7\u3001\u305d\u306e\u4ed6\u306e\u523a\u6fc0\u306b\u5fdc\u7b54\u3057\u3066\u3001\u7b4b\u8089\u5e79\u7d30\u80de\u304c\u6d3b\u6027\u5316\u3055\u308c\u3066\u640d\u50b7\u3057\u305f\u7b4b\u7dda\u7dad\u306b\u878d\u5408\u3057\u3066\u7b4b\u8089\u306e\u640d\u50b7\u3092\u4fee\u5fa9\u3059\u308b\u306e\u3067\u3059\u3002<\/p>\n\n\n\n

\u7b4b\u8089\u5e79\u7d30\u80de\u3092\u6d3b\u6027\u5316\u3057\u3001\u7b4b\u8089\u5e79\u7d30\u80de\u306e\u5897\u6b96\u3068\u5206\u5316\u3092\u9069\u6642\u306b\u4fc3\u9032\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u307e\u3060\u306f\u3063\u304d\u308a\u8abf\u3079\u3089\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n\n\n\n

\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u7406\u89e3\u3059\u308b\u305f\u3081\u306b\u306f\u7b4b\u8089\u306e\u640d\u50b7\u3084\u7b4b\u8089\u306e\u5909\u6027\u75be\u60a3\u306e\u518d\u751f\u6cbb\u7642\u306e\u958b\u767a\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

\u708e\u75c7\u3068\u7b4b\u8089\u518d\u751f\u306e\u95a2\u4fc2\u306b\u3064\u3044\u3066<\/strong><\/p>\n\n\n\n

\u6025\u6027\u708e\u75c7\u306f\u7b4b\u8089\u58ca\u6b7b\u6bb5\u968e\u304b\u3089\u518d\u751f\u6bb5\u968e\u3078\u306e\u8ee2\u63db\u3092\u8a98\u767a\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

\u6025\u6027\u708e\u75c7\u3068\u514d\u75ab\u7d30\u80de\u306f\u3001\u7b4b\u8089\u518d\u751f\u306e\u307b\u307c\u5168\u3066\u306e\u6bb5\u968e\u3067\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

\u708e\u75c7\u3068\u7b4b\u8089\u518d\u751f\u306b\u95a2\u3059\u308b\u30d5\u30a7\u30fc\u30ba<\/strong><\/p>\n\n\n\n

\u30d5\u30a7\u30fc\u30ba\uff11<\/strong><\/p>\n\n\n\n

\u521d\u671f\u6bb5\u968e(\u597d\u4e2d\u7403\u3001\u80a5\u6e80\u7d30\u80de)<\/p>\n\n\n\n

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\u7b4b\u8089\u304c\u640d\u50b7\u3059\u308b\u3068\u7d30\u80de\u306e\u5185\u5bb9\u7269\u3068\u8d70\u5316\u6027\u56e0\u5b50\u304c\u7d30\u80de\u5916\u7a7a\u9593\u306b\u653e\u51fa\u3055\u308c\u3001\u514d\u75ab\u7d30\u80de\u3092\u8a98\u767a\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

\u80a5\u6e80\u7d30\u80de\u3084\u597d\u4e2d\u7403\u306a\u3069\u306e\u514d\u75ab\u7d30\u80de\u306f\u3001\u640d\u50b7\u90e8\u4f4d\u3067\u30c0\u30e1\u30fc\u30b8\u3092\u53d7\u3051\u305f\u7b4b\u7dda\u7dad\u3092\u53d6\u308a\u9664\u304f\u3053\u3068\u3092\u884c\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u640d\u50b7\u5f8c\u306e\u7b4b\u8089\u518d\u751f\u306e\u521d\u671f\u6bb5\u968e\u306e\u4e3b\u306a\u30a4\u30d9\u30f3\u30c8\u306b\u306f\u3001\u7b4b\u7dda\u7dad\u306e\u58ca\u6b7b\u3001\u75c5\u5909\u306e\u62e1\u5927\u3001\u7834\u7247\u306e\u9664\u53bb\u306a\u3069\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u514d\u75ab\u7d30\u80de\u306e\u6700\u521d\u306e\u6ce2\u306f\u7b4b\u8089\u518d\u751f\u306e\u521d\u671f\u6bb5\u968e\u3067\u8d77\u3053\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u514d\u75ab\u7cfb\u306f\u3001\u7b4b\u8089\u75c5\u5909\u90e8\u4f4d\u306e\u640d\u50b7\u3057\u305f\u7dda\u7dad\u304b\u3089\u306e\u7d30\u80de\u7834\u7247\u3068\u7d30\u80de\u5185\u5bb9\u7269\u306e\u6f0f\u51fa\u306b\u3088\u3063\u3066\u6d3b\u6027\u5316\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

\u30d5\u30a7\u30fc\u30ba1 \u88dc\u4f53\u7cfb<\/strong><\/p>\n\n\n\n

\u88dc\u4f53\u7cfb\u306f\u7b4b\u8089\u640d\u50b7\u306e\u6700\u521d\u306e\u30bb\u30f3\u30b5\u30fc\u3068\u3057\u3066\u6a5f\u80fd\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

\u640d\u50b7\u3057\u305f\u7b4b\u8089\u306e\u88dc\u4f53\u7cfb\u306e\u6d3b\u6027\u5316\u306f\u3001\u75c5\u5909\u90e8\u4f4d\u3078\u306e\u597d\u4e2d\u7403\u3068\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306e\u6d78\u6f64\u3092\u5f15\u304d\u8d77\u3053\u3059\u3002<\/p>\n\n\n\n

\u30d5\u30a7\u30fc\u30ba1 \u80a5\u6e80\u7d30\u80de<\/strong><\/p>\n\n\n\n

\u80a5\u6e80\u7d30\u80de\u306e\u8131\u9846\u7c92\u306f\u3001\u8ca0\u50b7\u3057\u305f\u7b4b\u7dda\u7dad\u306e\u5468\u56f2\u306e\u9818\u57df\u3067\u3057\u3070\u3057\u3070\u89b3\u5bdf\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

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\u30d5\u30a7\u30fc\u30ba1\u597d\u4e2d\u7403<\/strong><\/p>\n\n\n\n

\u597d\u4e2d\u7403\u306f\u69d8\u3005\u306a\u56e0\u5b50\u3092\u653e\u51fa\u3057\u7b4b\u8089\u306e\u4ee3\u8b1d\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

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\u30d5\u30a7\u30fc\u30ba\uff12<\/strong>\u3000<\/p>\n\n\n\n

\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3068T\u7d30\u80de<\/p>\n\n\n\n

\u7b4b\u8089\u518d\u751f\u306e\u7b2c\u4e8c\u6bb5\u968e\u306f\u3001\u7b4b\u8089\u5e79\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3068\u62e1\u5927\u306b\u3088\u3063\u3066\u7279\u5fb4\u3065\u3051\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

\u3053\u306e\u6bb5\u968e\u306f\u9069\u5fdc\u514d\u75ab\u306e\u6d3b\u6027\u5316\u3068\u514d\u75ab\u7d30\u80de\u306e\u7b2c\u4e8c\u306e\u6d78\u6f64\u3092\u4f34\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u30d5\u30a7\u30fc\u30ba\uff12\u3000\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8<\/strong><\/p>\n\n\n\n

\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306f\u640d\u50b7\u76f4\u5f8c\u306b\u597d\u4e2d\u7403\u306b\u3088\u3063\u3066\u7b4b\u8089\u640d\u50b7\u90e8\u306b\u52d5\u54e1\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306f\u9aa8\u683c\u7b4b\u518d\u751f\u306e\u8abf\u7bc0\u306b\u304a\u3044\u3066\u4e2d\u5fc3\u7684\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u306e\u3067\u3059\u3002<\/p>\n\n\n\n

\u30d5\u30a7\u30fc\u30ba2 TNF-\u03b1<\/strong><\/p>\n\n\n\n

TNF-\u03b1\u306f\u7b4b\u8089\u306e\u518d\u751f\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

TNF-\u03b1\u306f\u7b4b\u8089\u306e\u640d\u50b7\u90e8\u4f4d\u306b\u7b4b\u8089\u5e79\u7d30\u80de\u3092\u5f15\u304d\u4ed8\u3051\u3001\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u7b4b\u8089\u5e79\u7d30\u80de\u306e\u5897\u6b96\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

\u30d5\u30a7\u30fc\u30ba2 IL-6<\/strong><\/p>\n\n\n\n

IL-6\u306f\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3001T\u7d30\u80de\u3001\u7b4b\u7dda\u7dad\u3092\u542b\u3080\u8907\u6570\u306e\u7d30\u80de\u578b\u306b\u3088\u3063\u3066\u7523\u751f\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

IL-6\u306f\u7b4b\u82bd\u7d30\u80de\u306e\u79fb\u52d5\u3001\u5897\u6b96\u3001\u5206\u5316\u3092\u523a\u6fc0\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u306e\u3067\u3059\u3002<\/p>\n\n\n\n

\u30d5\u30a7\u30fc\u30ba2 T\u7d30\u80de<\/strong><\/p>\n\n\n\n

T\u7d30\u80de\u306f\u3001\u514d\u75ab\u7d30\u80de\u6d78\u6f64\u306e\u7b2c\u4e8c\u6ce2\u3067\u51fa\u73fe\u3059\u308b\u4e3b\u8981\u306a\u7d30\u80de\u96c6\u56e3\u3067\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u5927\u91cf\u306b\u7523\u751f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

T\u7d30\u80de\u306b\u3088\u3063\u3066\u5206\u6ccc\u3055\u308c\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3068\u6210\u9577\u56e0\u5b50\u304c\u3001\u7b4b\u8089\u306e\u518d\u751f\u3092\u4fc3\u9032\u3059\u308b\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u30d5\u30a7\u30fc\u30ba3<\/strong><\/p>\n\n\n\n

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