{"id":317,"date":"2023-01-10T04:54:21","date_gmt":"2023-01-09T19:54:21","guid":{"rendered":"https:\/\/fujimakimedical.com\/?p=317"},"modified":"2023-01-20T02:47:33","modified_gmt":"2023-01-19T17:47:33","slug":"%e7%ad%8b%e8%82%89%e6%90%8d%e5%82%b7%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e6%88%90%e9%95%b7%e5%9b%a0%e5%ad%90%e3%81%ae%e6%b2%bb%e7%99%82","status":"publish","type":"post","link":"https:\/\/fujimakimedical.com\/?p=317","title":{"rendered":"\u7b4b\u8089\u640d\u50b7\u306b\u5bfe\u3059\u308b\u6210\u9577\u56e0\u5b50\u306e\u6cbb\u7642"},"content":{"rendered":"\n<p>bFGF\u306a\u3069\u306e\u6210\u9577\u56e0\u5b50\u306f\u71b1\u50b7\u306e\u6cbb\u7642\u6642\u306b\u5e83\u304f\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4eca\u56de\u7d39\u4ecb\u3059\u308b\u8ad6\u6587\u306f\u30e9\u30c3\u30c8\u306e\u4e0b\u80a2\u7b4b\u8089\u640d\u50b7\u30e2\u30c7\u30eb\u306b\u5bfe\u3057\u3066\u30b1\u30e9\u30c1\u30f3\u7531\u6765\u306e\u8db3\u5834\u3068\u6210\u9577\u56e0\u5b50(bFGF)\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u6cbb\u7642\u306e\u30ec\u30d3\u30e5\u30fc\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u8a2d\u5b9a\u3057\u3066\u3044\u308b\u6cbb\u7642\u6761\u4ef6\u304c\u591a\u304f\u8aad\u3080\u4e0a\u3067\u5c11\u3057\u8907\u96d1\u3067\u3059\u304c\u3001<mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-vivid-red-color\"><em><strong>\u7d50\u8ad6\u3068\u3057\u3066\u306f\u30b1\u30e9\u30c1\u30f3\u7531\u6765\u306e\u8db3\u5834\u3068bFGF\u306e\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u7b4b\u8089\u518d\u751f\u306e\u4fc3\u9032\u3068\u7dda\u7dad\u5316\u306e\u6291\u5236<\/strong><\/em><\/mark>\u304c\u8a8d\u3081\u3089\u308c\u305f\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/fujimakimedical.com\/wp-content\/uploads\/2023\/01\/Writers-block-bro-1-1024x1024.png\" alt=\"\" class=\"wp-image-319\" width=\"369\" height=\"369\" srcset=\"https:\/\/fujimakimedical.com\/wp-content\/uploads\/2023\/01\/Writers-block-bro-1-1024x1024.png 1024w, https:\/\/fujimakimedical.com\/wp-content\/uploads\/2023\/01\/Writers-block-bro-1-300x300.png 300w, https:\/\/fujimakimedical.com\/wp-content\/uploads\/2023\/01\/Writers-block-bro-1-150x150.png 150w, https:\/\/fujimakimedical.com\/wp-content\/uploads\/2023\/01\/Writers-block-bro-1-768x768.png 768w, https:\/\/fujimakimedical.com\/wp-content\/uploads\/2023\/01\/Writers-block-bro-1-1536x1536.png 1536w, https:\/\/fujimakimedical.com\/wp-content\/uploads\/2023\/01\/Writers-block-bro-1-700x700.png 700w, https:\/\/fujimakimedical.com\/wp-content\/uploads\/2023\/01\/Writers-block-bro-1.png 2000w\" sizes=\"auto, (max-width: 369px) 100vw, 369px\" \/><\/figure>\n\n\n\n<p>\u5185\u5bb9\u306f\u4e0b\u8a18\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4f53\u7a4d\u7b4b\u8089\u640d\u5931 (VML) \u640d\u50b7\u306f\u3001\u9aa8\u683c\u7b4b\u306e\u304b\u306a\u308a\u306e\u56fa\u6709\u306e\u518d\u751f\u80fd\u529b\u3092\u8d85\u3048\u3066\u304a\u308a\u3001\u305d\u306e\u7d50\u679c\u3001\u6052\u4e45\u7684\u306a\u6a5f\u80fd\u7684\u304a\u3088\u3073\u7f8e\u5bb9\u4e0a\u306e\u6b20\u9665\u304c\u751f\u3058\u307e\u3059\u3002<\/p>\n\n\n\n<p>VML \u304a\u3088\u3073 VML \u69d8\u306e\u50b7\u5bb3\u306f\u3001\u5916\u50b7\u3084\u624b\u8853\u3001\u306a\u3089\u3073\u306b\u5148\u5929\u6027\u304a\u3088\u3073\u5f8c\u5929\u6027\u306e\u75be\u60a3\/\u75c7\u5019\u7fa4\u306e\u30db\u30b9\u30c8\u306b\u3088\u308a\u3001\u8ecd\u4eba\u304a\u3088\u3073\u6c11\u9593\u4eba\u306b\u767a\u751f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u73fe\u5728\u306e\u6cbb\u7642\u9078\u629e\u80a2\u306f\u9650\u3089\u308c\u3066\u304a\u308a\u3001\u7b4b\u8089\u306e\u3088\u308a\u5b8c\u5168\u306a\u6a5f\u80fd\u518d\u751f\u306b\u306f\u65b0\u3057\u3044\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u6f5c\u5728\u7684\u306a\u89e3\u6c7a\u7b56\u306f\u3001\u518d\u751f\u7642\u6cd5\u306b\u5927\u304d\u306a\u53ef\u80fd\u6027\u3092\u79d8\u3081\u3066\u3044\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u3001\u4eba\u6bdb\u7531\u6765\u306e\u30b1\u30e9\u30c1\u30f3 (KN) \u751f\u4f53\u6750\u6599\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u7814\u7a76\u306e\u76ee\u7684\u306f\u3001\u30e9\u30c3\u30c8\u524d\u811b\u9aa8\u7b4b (TA) \u306b\u5916\u79d1\u7684\u306b\u4f5c\u6210\u3055\u308c\u305f VML \u640d\u50b7\u306b\u304a\u3051\u308b\u6a5f\u80fd\u7684\u306a\u7b4b\u8089\u518d\u751f\u306e\u305f\u3081\u306e\u7d30\u80de\u304a\u3088\u3073\/\u307e\u305f\u306f\u6210\u9577\u56e0\u5b50\u9001\u9054\u30d3\u30d2\u30af\u30eb\u3068\u3057\u3066\u306e\u30b1\u30e9\u30c1\u30f3 \u30d2\u30c9\u30ed\u30b2\u30eb\u88fd\u5264\u306e\u6709\u7528\u6027\u3092\u8a55\u4fa1\u3059\u308b\u3053\u3068\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p>VML \u640d\u50b7\u306f\u3001\u9aa8\u683c\u7b4b\u524d\u99c6\u7d30\u80de (MPC)\u3001\u304a\u3088\u3073\/\u307e\u305f\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u69d8\u6210\u9577\u56e0\u5b50 1 (IGF-1)\u3001\u304a\u3088\u3073\/\u307e\u305f\u306f\u5869\u57fa\u6027\u7dda\u7dad\u82bd\u7d30\u80de\u6210\u9577\u56e0\u5b50 (bFGF) \u306e\u975e\u5b58\u5728\u4e0b\u304a\u3088\u3073\u5b58\u5728\u4e0b\u3067\u3001KN \u30d2\u30c9\u30ed\u30b2\u30eb\u3067\u6cbb\u7642\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306b\u306f\u3001\u4fee\u5fa9\u306e\u306a\u3044 VML \u640d\u50b7 (NR)\u3001\u304a\u3088\u3073\u8180\u80f1\u7121\u7d30\u80de\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u306e\u79fb\u690d (BAM\u3001\u7d30\u80de\u306a\u3057) \u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>VML\u640d\u50b7\u306e8\u9031\u9593\u5f8c\u306b\u5b9f\u65bd\u3055\u308c\u305f\u6700\u521d\u306e\u7814\u7a76\u3067\u306f\u3001<\/p>\n\n\n\n<p>\u6210\u9577\u56e0\u5b50\uff08KN\u3001KN + IGF-1\u3001KN + bFGF\u3001\u304a\u3088\u3073KN + IGF-1 + bFGF\u3001<em>\u305d\u308c\u305e\u308cn = 8) \u306f\u3001NR (&nbsp;n<\/em>&nbsp;\u2009= 7)\u3001BAM (&nbsp;<em>n<\/em>&nbsp;\u2009= 8)\u3001\u307e\u305f\u306f\u30b1\u30e9\u30c1\u30f3 \u30cf\u30a4\u30c9\u30ed\u30b2\u30eb\u3078\u306e MPC \u306e\u8ffd\u52a0 (KN+MPC\u3001KN+MPC+IGF-1\u3001KN+ )\u2009\u3088\u308a\u3082\u6709\u610f\u306b\u512a\u308c\u305f\u6a5f\u80fd\u56de\u5fa9\u3092\u53ef\u80fd\u306b\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>&nbsp;MPC+bFGF\u3001\u304a\u3088\u3073 KN+MPC+IGF-1+bFGF\u3001\u305d\u308c\u305e\u308c<em>n<\/em>&nbsp;\u2009= 8) (&nbsp;<em>p<\/em>\u2009&lt; 0.05)\u30022 \u756a\u76ee\u306e\u4e00\u9023\u306e\u7814\u7a76\u3067\u306f\u3001\u7d30\u80de\u306e\u975e\u5b58\u5728\u4e0b\u3067\u30b1\u30e9\u30c1\u30f3 \u30d2\u30c9\u30ed\u30b2\u30eb\u3092\u9069\u7528\u3057\u305f\u5f8c\u3001VML \u640d\u50b7\u5f8c 12 \u9031\u9593\u3082\u306e\u6a5f\u80fd\u56de\u5fa9\u3092\u8abf\u3079\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p><mark style=\"background-color:#ffffff\" class=\"has-inline-color has-vivid-red-color\"><em><strong>NR \u304a\u3088\u3073 BAM \u79fb\u690d\u3068\u6bd4\u8f03\u3057\u3066\u3001KN\u3001KN+bFGF\u3001\u304a\u3088\u3073 KN+IGF+bFGF \u30b0\u30eb\u30fc\u30d7\u306e\u6a5f\u80fd\u56de\u5fa9\u306e\u6642\u9593\u4f9d\u5b58\u6027\u306e\u6709\u610f\u306a\u5897\u52a0\u304c\u89b3\u5bdf\u3055\u308c\u3001\u53ef\u80fd\u306a\u6700\u5927\u6a5f\u80fd\u56de\u5fa9\u306e 90% \u3092\u9054\u6210\u3057\u307e\u3057\u305f\u3002<\/strong><\/em><\/mark><\/p>\n\n\n\n<p>VML \u640d\u50b7\u5f8c 12 \u9031\u9593\u3067\u63a1\u53d6\u3057\u305f\u7d44\u7e54\u304b\u3089\u306e\u7d44\u7e54\u5b66\u7684\u6240\u898b\u306f\u3001BAM \u3068 NR \u306e\u4e21\u65b9\u3068\u6bd4\u8f03\u3057\u3066\u3001\u3059\u3079\u3066\u306e\u30b1\u30e9\u30c1\u30f3\u6cbb\u7642\u30b0\u30eb\u30fc\u30d7\u3067\u306e\u65b0\u751f\u7b4b\u7d44\u7e54\u5f62\u6210\u306e\u6709\u610f\u306a\u5897\u52a0\u3068\u7dda\u7dad\u75c7\u306e\u6e1b\u5c11\u3092\u8a18\u9332\u3057\u307e\u3057\u305f\u3002\u7d50\u8ad6\u3068\u3057\u3066\u3001\u30b1\u30e9\u30c1\u30f3 \u30cf\u30a4\u30c9\u30ed\u30b2\u30eb\u79fb\u690d\u306f\u3001\u3052\u3063\u6b6f\u985e\u306e TA \u7b4b\u8089\u306b\u5bfe\u3059\u308b VML \u640d\u50b7\u5f8c\u306e\u6a5f\u80fd\u7684\u8ee2\u5e30\u306e\u7d71\u8a08\u7684\u306b\u6709\u610f\u3067\u751f\u7406\u5b66\u7684\u306b\u95a2\u9023\u3059\u308b\u6539\u5584\u3092\u4fc3\u9032\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>\u5f15\u7528\u6587\u732e<\/p>\n\n\n\n<p>Passipieri, J. A., et al. &#8220;Keratin hydrogel enhances in vivo skeletal muscle function in a rat model of volumetric muscle loss.&#8221;&nbsp;<em>Tissue Engineering Part A<\/em>&nbsp;23.11-12 (2017): 556-571.<\/p>\n\n\n\n<p><a href=\"https:\/\/storyset.com\/idea\">Idea illustrations by Storyset<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>bFGF\u306a\u3069\u306e\u6210\u9577\u56e0\u5b50\u306f\u71b1\u50b7\u306e\u6cbb\u7642\u6642\u306b\u5e83\u304f\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002 \u4eca\u56de\u7d39\u4ecb\u3059\u308b\u8ad6\u6587\u306f\u30e9\u30c3\u30c8\u306e\u4e0b\u80a2\u7b4b\u8089\u640d\u50b7\u30e2\u30c7\u30eb\u306b\u5bfe\u3057\u3066\u30b1\u30e9\u30c1\u30f3\u7531\u6765\u306e\u8db3\u5834\u3068\u6210\u9577\u56e0\u5b50(bFGF)\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u6cbb\u7642\u306e\u30ec\u30d3\u30e5\u30fc\u3067\u3059\u3002 \u8a2d\u5b9a\u3057\u3066\u3044\u308b\u6cbb\u7642\u6761\u4ef6\u304c\u591a\u304f\u8aad\u3080&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[6],"tags":[],"class_list":["post-317","post","type-post","status-publish","format-standard","hentry","category-6"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/fujimakimedical.com\/index.php?rest_route=\/wp\/v2\/posts\/317","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fujimakimedical.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/fujimakimedical.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/fujimakimedical.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/fujimakimedical.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=317"}],"version-history":[{"count":2,"href":"https:\/\/fujimakimedical.com\/index.php?rest_route=\/wp\/v2\/posts\/317\/revisions"}],"predecessor-version":[{"id":356,"href":"https:\/\/fujimakimedical.com\/index.php?rest_route=\/wp\/v2\/posts\/317\/revisions\/356"}],"wp:attachment":[{"href":"https:\/\/fujimakimedical.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=317"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/fujimakimedical.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=317"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/fujimakimedical.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=317"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}