{"id":512,"date":"2024-05-19T19:44:59","date_gmt":"2024-05-19T10:44:59","guid":{"rendered":"https:\/\/fujimakimedical.com\/?p=512"},"modified":"2024-05-19T19:46:13","modified_gmt":"2024-05-19T10:46:13","slug":"aga%e6%b2%bb%e7%99%82%e8%96%ac%e3%81%a7%e5%88%9d%e6%9c%9f%e8%84%b1%e6%af%9b%e3%81%af%e6%9c%ac%e5%bd%93%e3%81%ab%e8%b5%b7%e3%81%93%e3%82%8b%ef%bc%9f%ef%bc%88%e6%b2%bb%e7%99%82%e8%96%ac%e3%81%ae","status":"publish","type":"post","link":"https:\/\/fujimakimedical.com\/?p=512","title":{"rendered":"AGA\u6cbb\u7642\u85ac\u3067\u521d\u671f\u8131\u6bdb\u306f\u672c\u5f53\u306b\u8d77\u3053\u308b\uff1f\uff08\u6cbb\u7642\u85ac\u306e\u79d1\u5b66\u7684\u8003\u5bdf\uff09"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">\u6f2b\u7136\u3068AGA\u6cbb\u7642\u85ac\u3067\u521d\u671f\u8131\u6bdb\u304c\u8d77\u3053\u308b\u3068\u52d8\u9055\u3044\u3055\u308c\u304c\u3061\u3067\u3059\u304c\u3001\u3053\u308c\u306f\u6b63\u3057\u304f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><em>\u30df\u30ce\u30ad\u30b7\u30b8\u30eb\u3067\u306f\u521d\u671f\u306e\u8131\u6bdb\u304c\u8d77\u3053\u308a\u3046\u308b\u4e00\u65b9\u3067\u3001\u30d5\u30a3\u30ca\u30b9\u30c6\u30ea\u30c9\u3067\u306f\u307b\u3068\u3093\u3069\u8d77\u3053\u308a\u307e\u305b\u3093\u3002<\/em><\/strong><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u521d\u671f\u306e\u8131\u6bdb\u3068\u6cbb\u7642\u85ac\u306e\u6a5f\u5e8f\u306b\u3064\u3044\u3066<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u6bdb\u9aea\u6cbb\u7642\u306b\u304a\u3044\u3066\u3001\u521d\u671f\u306e\u8131\u6bdb\uff08shedding\uff09\u306f\u7279\u306b\u30df\u30ce\u30ad\u30b7\u30b8\u30eb\u6cbb\u7642\u3067\u9855\u8457\u306b\u898b\u3089\u308c\u308b\u73fe\u8c61\u3067\u3059\u3002\u4e00\u65b9\u3067\u3001\u30d5\u30a3\u30ca\u30b9\u30c6\u30ea\u30c9\u4f7f\u7528\u6642\u306b\u306f\u307b\u3068\u3093\u3069\u5831\u544a\u3055\u308c\u307e\u305b\u3093\u3002\u3053\u3053\u3067\u306f\u3001\u521d\u671f\u306e\u8131\u6bdb\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u305d\u308c\u305e\u308c\u306e\u6cbb\u7642\u85ac\u306e\u4f5c\u7528\u6a5f\u5e8f\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u8aac\u660e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u30df\u30ce\u30ad\u30b7\u30b8\u30eb\u306e\u6a5f\u5e8f\u3068\u521d\u671f\u306e\u8131\u6bdb<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30df\u30ce\u30ad\u30b7\u30b8\u30eb<\/strong>\u306e\u4f7f\u7528\u306b\u3088\u3063\u3066\u8d77\u3053\u308b\u521d\u671f\u306e\u8131\u6bdb\u306f\u3001\u4e3b\u306bWnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u306e\u6d3b\u6027\u5316\u306b\u3088\u308b\u3082\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u30b7\u30b0\u30ca\u30eb\u306e\u6d3b\u6027\u5316<\/strong>:\n<ul class=\"wp-block-list\">\n<li>\u30df\u30ce\u30ad\u30b7\u30b8\u30eb\u306fWnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3067\u3001\u6bdb\u5305\u306e\u6210\u9577\u671f\uff08anagen phase\uff09\u3078\u306e\u79fb\u884c\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002Wnt\u30b7\u30b0\u30ca\u30eb\u306f\u3001\u6bdb\u5305\u306e\u6210\u9577\u3068\u518d\u751f\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u53c2\u8003\u8ad6\u6587<\/strong>: Guo H, Yang K, Deng F, et al. (2020). &#8220;Minoxidil promotes hair growth through stimulation of epithelial \u03b2-catenin and dermal papilla-derived IGF-1&#8221;. <em>Biochemical and Biophysical Research Communications<\/em>. 525(4): 1085-1092.\n<ul class=\"wp-block-list\">\n<li>\u3053\u306e\u7814\u7a76\u3067\u306f\u3001\u30df\u30ce\u30ad\u30b7\u30b8\u30eb\u304cWnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u3092\u6d3b\u6027\u5316\u3057\u3001\u6bdb\u5305\u306e\u6210\u9577\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u6210\u9577\u671f\u3078\u306e\u79fb\u884c<\/strong>:\n<ul class=\"wp-block-list\">\n<li>Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u30b7\u30b0\u30ca\u30eb\u306e\u6d3b\u6027\u5316\u306b\u3088\u308a\u3001\u4f11\u6b62\u671f\uff08telogen phase\uff09\u306b\u3042\u308b\u6bdb\u5305\u304c\u6025\u901f\u306b\u6210\u9577\u671f\u306b\u79fb\u884c\u3057\u307e\u3059\u3002\u3053\u306e\u904e\u7a0b\u3067\u3001\u53e4\u3044\u4f11\u6b62\u671f\u306e\u6bdb\u304c\u629c\u3051\u843d\u3061\u3001\u65b0\u3057\u3044\u6210\u9577\u671f\u306e\u6bdb\u304c\u751f\u3048\u59cb\u3081\u308b\u305f\u3081\u3001\u4e00\u6642\u7684\u306a\u8131\u6bdb\u304c\u767a\u751f\u3057\u307e\u3059\u3002\u3053\u308c\u304c\u521d\u671f\u306e\u8131\u6bdb\uff08initial shedding\uff09\u3067\u3059\u3002<\/li>\n\n\n\n<li><strong>\u53c2\u8003\u8ad6\u6587<\/strong>: Olsen EA, et al. (2002). &#8220;A randomized clinical trial of 5% topical minoxidil versus 2% topical minoxidil and placebo in the treatment of androgenetic alopecia in men&#8221;. <em>Journal of the American Academy of Dermatology<\/em>. 47(3):377-385.\n<ul class=\"wp-block-list\">\n<li>\u3053\u306e\u7814\u7a76\u3067\u306f\u3001\u30df\u30ce\u30ad\u30b7\u30b8\u30eb\u4f7f\u7528\u8005\u306e\u9593\u3067\u521d\u671f\u306e\u8131\u6bdb\uff08initial shedding\uff09\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n\n\n\n<h3 class=\"wp-block-heading\">\u30d5\u30a3\u30ca\u30b9\u30c6\u30ea\u30c9\u306e\u6a5f\u5e8f\u3068\u521d\u671f\u306e\u8131\u6bdb\u306e\u6291\u5236<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30d5\u30a3\u30ca\u30b9\u30c6\u30ea\u30c9<\/strong>\u306f\u30015\u03b1-\u9084\u5143\u9175\u7d20\u306e\u963b\u5bb3\u85ac\u3067\u3042\u308a\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u304b\u3089\u30b8\u30d2\u30c9\u30ed\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\uff08DHT\uff09\u3078\u306e\u5909\u63db\u3092\u6291\u5236\u3057\u307e\u3059\u3002DHT\u306f\u6bdb\u5305\u306e\u30df\u30cb\u30c1\u30e5\u30a2\u5316\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u8131\u6bdb\u3092\u4fc3\u9032\u3059\u308b\u4e3b\u8981\u306a\u8981\u56e0\u3067\u3059\u3002\u30d5\u30a3\u30ca\u30b9\u30c6\u30ea\u30c9\u306e\u4f5c\u7528\u6a5f\u5e8f\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3059\uff1a<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>DHT\u306e\u6291\u5236<\/strong>:\n<ul class=\"wp-block-list\">\n<li>\u30d5\u30a3\u30ca\u30b9\u30c6\u30ea\u30c9\u306f\u30015\u03b1-\u9084\u5143\u9175\u7d20\u30bf\u30a4\u30d7II\u3092\u963b\u5bb3\u3057\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u304cDHT\u306b\u5909\u63db\u3055\u308c\u308b\u306e\u3092\u9632\u304e\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u982d\u76ae\u306eDHT\u6fc3\u5ea6\u304c\u4f4e\u4e0b\u3057\u3001DHT\u306b\u3088\u308b\u6bdb\u5305\u306e\u30df\u30cb\u30c1\u30e5\u30a2\u5316\u304c\u6291\u5236\u3055\u308c\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u6bdb\u5305\u306e\u56de\u5fa9<\/strong>:\n<ul class=\"wp-block-list\">\n<li>DHT\u306e\u6fc3\u5ea6\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u3067\u3001\u30df\u30cb\u30c1\u30e5\u30a2\u5316\u3055\u308c\u305f\u6bdb\u5305\u304c\u5f90\u3005\u306b\u56de\u5fa9\u3057\u3001\u901a\u5e38\u306e\u6210\u9577\u671f\u306b\u623b\u308a\u307e\u3059\u3002\u3053\u306e\u30d7\u30ed\u30bb\u30b9\u306f\u7de9\u3084\u304b\u306b\u9032\u884c\u3057\u3001\u6025\u6fc0\u306a\u6bdb\u306e\u8131\u843d\uff08\u521d\u671f\u306e\u8131\u6bdb\uff09\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u6bdb\u9aea\u30b5\u30a4\u30af\u30eb\u306e\u5b89\u5b9a\u5316<\/strong>:\n<ul class=\"wp-block-list\">\n<li>\u30d5\u30a3\u30ca\u30b9\u30c6\u30ea\u30c9\u306e\u4f7f\u7528\u306b\u3088\u308a\u3001\u6bdb\u9aea\u30b5\u30a4\u30af\u30eb\u304c\u5b89\u5b9a\u5316\u3057\u3001\u65b0\u3057\u3044\u6bdb\u9aea\u306e\u6210\u9577\u304c\u4fc3\u9032\u3055\u308c\u307e\u3059\u304c\u3001\u3053\u308c\u306f\u6025\u901f\u306a\u30b5\u30a4\u30af\u30eb\u5909\u5316\u3092\u4f34\u308f\u306a\u3044\u305f\u3081\u3001\u521d\u671f\u306e\u8131\u6bdb\u306f\u307b\u3068\u3093\u3069\u898b\u3089\u308c\u307e\u305b\u3093\u3002<\/li>\n\n\n\n<li><strong>\u53c2\u8003\u8ad6\u6587<\/strong>: Kaufman KD, Olsen EA, Whiting D, et al. (1998). &#8220;Finasteride in the treatment of men with androgenetic alopecia&#8221;. <em>Journal of the American Academy of Dermatology<\/em>. 39(4): 578-589.\n<ul class=\"wp-block-list\">\n<li>\u3053\u306e\u7814\u7a76\u3067\u306f\u3001\u30d5\u30a3\u30ca\u30b9\u30c6\u30ea\u30c9\u304cDHT\u306e\u6291\u5236\u3092\u901a\u3058\u3066\u6bdb\u5305\u306e\u30df\u30cb\u30c1\u30e5\u30a2\u5316\u3092\u9006\u8ee2\u3055\u305b\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u521d\u671f\u306e\u8131\u6bdb\u306e\u5831\u544a\u306f\u307b\u3068\u3093\u3069\u3042\u308a\u307e\u305b\u3093\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n\n\n\n<h3 class=\"wp-block-heading\">\u307e\u3068\u3081<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u30df\u30ce\u30ad\u30b7\u30b8\u30eb\u306b\u3088\u308b\u521d\u671f\u306e\u8131\u6bdb\u306f\u3001\u4e3b\u306bWnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u306e\u6d3b\u6027\u5316\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u307e\u3059\u3002\u3053\u306e\u7d4c\u8def\u306f\u3001\u6bdb\u5305\u306e\u6210\u9577\u671f\u3078\u306e\u6025\u901f\u306a\u79fb\u884c\u3092\u4fc3\u9032\u3057\u3001\u7d50\u679c\u3068\u3057\u3066\u521d\u671f\u306e\u8131\u6bdb\u304c\u767a\u751f\u3057\u307e\u3059\u3002\u4e00\u65b9\u3001\u30d5\u30a3\u30ca\u30b9\u30c6\u30ea\u30c9\u306fDHT\u306e\u6291\u5236\u3092\u901a\u3058\u3066\u6bdb\u5305\u306e\u30df\u30cb\u30c1\u30e5\u30a2\u5316\u3092\u7de9\u3084\u304b\u306b\u9006\u8ee2\u3055\u305b\u308b\u305f\u3081\u3001\u6025\u6fc0\u306a\u6bdb\u306e\u8131\u843d\u3092\u5f15\u304d\u8d77\u3053\u3055\u305a\u3001\u521d\u671f\u306e\u8131\u6bdb\u306f\u307b\u3068\u3093\u3069\u767a\u751f\u3057\u307e\u305b\u3093\u3002\u3053\u308c\u3089\u306e\u73fe\u8c61\u306f\u3001\u305d\u308c\u305e\u308c\u306e\u85ac\u5264\u306e\u7570\u306a\u308b\u4f5c\u7528\u6a5f\u5e8f\u306b\u57fa\u3065\u3044\u3066\u3044\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6f2b\u7136\u3068AGA\u6cbb\u7642\u85ac\u3067\u521d\u671f\u8131\u6bdb\u304c\u8d77\u3053\u308b\u3068\u52d8\u9055\u3044\u3055\u308c\u304c\u3061\u3067\u3059\u304c\u3001\u3053\u308c\u306f\u6b63\u3057\u304f\u3042\u308a\u307e\u305b\u3093\u3002 \u30df\u30ce\u30ad\u30b7\u30b8\u30eb\u3067\u306f\u521d\u671f\u306e\u8131\u6bdb\u304c\u8d77\u3053\u308a\u3046\u308b\u4e00\u65b9\u3067\u3001\u30d5\u30a3\u30ca\u30b9\u30c6\u30ea\u30c9\u3067\u306f\u307b\u3068\u3093\u3069\u8d77\u3053\u308a\u307e\u305b\u3093\u3002 \u521d\u671f\u306e\u8131\u6bdb\u3068\u6cbb\u7642\u85ac\u306e\u6a5f\u5e8f\u306b\u3064\u3044\u3066 \u6bdb\u9aea\u6cbb\u7642\u306b\u304a&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[5],"tags":[],"class_list":["post-512","post","type-post","status-publish","format-standard","hentry","category-5"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/fujimakimedical.com\/index.php?rest_route=\/wp\/v2\/posts\/512","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fujimakimedical.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/fujimakimedical.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/fujimakimedical.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/fujimakimedical.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=512"}],"version-history":[{"count":1,"href":"https:\/\/fujimakimedical.com\/index.php?rest_route=\/wp\/v2\/posts\/512\/revisions"}],"predecessor-version":[{"id":513,"href":"https:\/\/fujimakimedical.com\/index.php?rest_route=\/wp\/v2\/posts\/512\/revisions\/513"}],"wp:attachment":[{"href":"https:\/\/fujimakimedical.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=512"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/fujimakimedical.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=512"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/fujimakimedical.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=512"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}