{"id":658,"date":"2025-08-10T08:34:53","date_gmt":"2025-08-09T23:34:53","guid":{"rendered":"https:\/\/fujimakimedical.com\/?p=658"},"modified":"2025-08-10T08:34:53","modified_gmt":"2025-08-09T23:34:53","slug":"%e3%83%95%e3%82%a3%e3%83%8a%e3%82%b9%e3%83%86%e3%83%aa%e3%83%89%ef%bc%88%e3%83%97%e3%83%ad%e3%83%9a%e3%82%b7%e3%82%a2%ef%bc%89%e3%81%ae%e6%89%bf%e8%aa%8d%e7%b5%8c%e7%b7%af%e3%81%a80-2mg%e8%a3%bd","status":"publish","type":"post","link":"https:\/\/fujimakimedical.com\/?p=658","title":{"rendered":"\u30d5\u30a3\u30ca\u30b9\u30c6\u30ea\u30c9\uff08\u30d7\u30ed\u30da\u30b7\u30a2\uff09\u306e\u627f\u8a8d\u7d4c\u7def\u30680.2mg\u88fd\u5264\u306e\u73fe\u72b6"},"content":{"rendered":"\n<h3 class=\"wp-block-heading\">\u2014 FDA\u627f\u8a8d\u304b\u3089\u539a\u52b4\u7701\u627f\u8a8d\u3001\u5e02\u5834\u6dd8\u6c70\u307e\u3067\u306e\u5168\u8c8c \u2014<\/h3>\n\n\n\n<h3 class=\"wp-block-heading\">1. \u30d5\u30a3\u30ca\u30b9\u30c6\u30ea\u30c9\u3068\u306f<\/h3>\n\n\n\n<p>\u30d5\u30a3\u30ca\u30b9\u30c6\u30ea\u30c9\u306f\u30015\u03b1\u9084\u5143\u9175\u7d20II\u578b\u3092\u963b\u5bb3\u3057\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u304b\u3089\u30b8\u30d2\u30c9\u30ed\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\uff08DHT\uff09\u3078\u306e\u5909\u63db\u3092\u6291\u5236\u3059\u308b\u7d4c\u53e3\u85ac\u3067\u3059\u3002DHT\u306f\u524d\u7acb\u817a\u80a5\u5927\u75c7\uff08BPH\uff09\u3084\u7537\u6027\u578b\u8131\u6bdb\u75c7\uff08AGA\uff09\u306e\u767a\u75c7\u306b\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u305d\u306e\u6291\u5236\u306f\u81e8\u5e8a\u7684\u306b\u6709\u52b9\u3068\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u5f53\u521d\u306fBPH\u6cbb\u7642\u85ac\uff085 mg\u88fd\u5264\u3001\u5546\u54c1\u540d\u30d7\u30ed\u30b9\u30ab\u30fc\uff09\u3068\u3057\u3066\u958b\u767a\u30fb\u627f\u8a8d\u3055\u308c\u307e\u3057\u305f\u304c\u3001\u6cbb\u7642\u4e2d\u306e\u60a3\u8005\u3067\u6bdb\u9aea\u5897\u52a0\u304c\u5076\u767a\u7684\u306b\u89b3\u5bdf\u3055\u308c\u3001AGA\u6cbb\u7642\u85ac\u3068\u3057\u3066\u306e\u958b\u767a\u304c\u958b\u59cb\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">2. FDA\u306b\u3088\u308bAGA\u9069\u5fdc\u627f\u8a8d\u307e\u3067\u306e\u7d4c\u7def<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>1992\u5e746\u6708:<\/strong> \u30d5\u30a3\u30ca\u30b9\u30c6\u30ea\u30c95 mg\u9320\uff08\u30d7\u30ed\u30b9\u30ab\u30fc\uff09\u304cFDA\u306b\u3088\u308aBPH\u6cbb\u7642\u85ac\u3068\u3057\u3066\u627f\u8a8d\u3002<\/li>\n\n\n\n<li><strong>1993\u301c1995\u5e74:<\/strong> AGA\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u4f4e\u7528\u91cf\u8a66\u9a13\u958b\u59cb\u3002\u6d77\u5916\u7b2cII\u76f8\u8a66\u9a13\u30670.2 mg\u301c5 mg\u3092\u6bd4\u8f03\u3057\u305f\u7d50\u679c\u3001<strong>1 mg\u4ee5\u4e0a\u3067\u306f\u52b9\u679c\u304c\u307b\u307c\u540c\u7b49<\/strong>\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3001\u56fd\u969b\u958b\u767a\u306e\u6a19\u6e96\u7528\u91cf\u304c1 mg\u306b\u8a2d\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002<\/li>\n\n\n\n<li><strong>1997\u5e7412\u670819\u65e5:<\/strong> \u30d5\u30a3\u30ca\u30b9\u30c6\u30ea\u30c91 mg\u9320\uff08\u30d7\u30ed\u30da\u30b7\u30a2\uff09\u304c\u6210\u4eba\u7537\u6027AGA\u6cbb\u7642\u85ac\u3068\u3057\u3066FDA\u627f\u8a8d\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u4e3b\u8981\u81e8\u5e8a\u8a66\u9a13\uff08Kaufman\u3089, JAAD 1998\uff09<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5bfe\u8c61\uff1a18\u301c41\u6b73\u306eAGA\u7537\u60271,553\u4f8b<\/li>\n\n\n\n<li>\u4ecb\u5165\uff1a\u30d5\u30a3\u30ca\u30b9\u30c6\u30ea\u30c91 mg vs \u30d7\u30e9\u30bb\u30dc\u30012\u5e74\u9593<\/li>\n\n\n\n<li>\u7d50\u679c\uff1a\n<ul class=\"wp-block-list\">\n<li>1\u5e74\u5f8c\uff1a\u6bdb\u9aea\u672c\u6570 +107\u672c\uff08\u30d7\u30e9\u30bb\u30dc\u306f\u6e1b\u5c11\uff09<\/li>\n\n\n\n<li>2\u5e74\u5f8c\uff1a\u6bdb\u9aea\u672c\u6570 +138\u672c\uff08\u30d7\u30e9\u30bb\u30dc\u306f\u3055\u3089\u306b\u6e1b\u5c11\uff09<\/li>\n\n\n\n<li>\u5199\u771f\u5224\u5b9a\u30fb\u60a3\u8005\u8a55\u4fa1\u3068\u3082\u6709\u610f\u306a\u6539\u5584<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>\u5b89\u5168\u6027\uff1a\u6027\u6a5f\u80fd\u95a2\u9023\u526f\u4f5c\u75282%\u524d\u5f8c\u3001\u307b\u3068\u3093\u3069\u304c\u53ef\u9006\u7684<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">3. \u65e5\u672c\u306b\u304a\u3051\u308b\u958b\u767a\u3068\u627f\u8a8d<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>2001\u5e74:<\/strong> \u4e07\u6709\u88fd\u85ac\uff08\u73feMSD\uff09\u304c\u56fd\u5185\u6cbb\u9a13\u958b\u59cb\u3002<\/li>\n\n\n\n<li><strong>2004\u5e74:<\/strong> \u5ddd\u5cf6\u3089\u306b\u3088\u308b\u56fd\u5185\u7b2cII\/III\u76f8\u8a66\u9a13\uff08Eur J Dermatol 2004\uff09\u767a\u8868\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u56fd\u5185\u8a66\u9a13\u30c7\u30b6\u30a4\u30f3<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5bfe\u8c61\uff1aAGA\u7537\u6027414\u4f8b<\/li>\n\n\n\n<li>\u7fa4\u5206\u3051\uff1a0.2 mg\u30011 mg\u3001\u30d7\u30e9\u30bb\u30dc<\/li>\n\n\n\n<li>\u671f\u9593\uff1a48\u9031\u9593\uff08\u305d\u306e\u5f8c96\u9031\u307e\u3067\u5ef6\u9577\u8a66\u9a13\uff09<\/li>\n<\/ul>\n\n\n\n<p><strong>\u7d50\u679c\uff0848\u9031\u6642\u70b9\uff09<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u7528\u91cf<\/th><th>\u6539\u5584\u7387<\/th><th>\u6027\u6a5f\u80fd\u95a2\u9023\u526f\u4f5c\u7528<\/th><\/tr><\/thead><tbody><tr><td>0.2 mg<\/td><td>54.2%<\/td><td>1.5%<\/td><\/tr><tr><td>1 mg<\/td><td>58.3%<\/td><td>2.9%<\/td><\/tr><tr><td>\u30d7\u30e9\u30bb\u30dc<\/td><td>5.9%<\/td><td>2.2%<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6709\u52b9\u6027:<\/strong> 0.2 mg\u30681 mg\u306e\u5dee\u306f\u7d71\u8a08\u7684\u306b\u6709\u610f\u3067\u306f\u306a\u3057\u3002<\/li>\n\n\n\n<li><strong>\u5b89\u5168\u6027:<\/strong> \u526f\u4f5c\u7528\u767a\u73fe\u7387\u306f\u4f4e\u304f\u3001\u4e21\u7fa4\u306b\u5927\u5dee\u306a\u3057\u3002<\/li>\n\n\n\n<li><strong>\u9577\u671f\u8a66\u9a13:<\/strong> 96\u9031\u307e\u3067\u767a\u6bdb\u52b9\u679c\u304c\u6301\u7d9a\u3001\u526f\u4f5c\u7528\u983b\u5ea6\u3082\u4f4e\u3044\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">4. \u539a\u52b4\u7701\u627f\u8a8d\u306e\u7406\u7531\uff08\u5be9\u67fb\u5831\u544a\u66f8\u306e\u8996\u70b9\uff09<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>0.2 mg\u306f\u6709\u52b9\u6027\u304c\u78ba\u8a8d\u3055\u308c\u3001\u526f\u4f5c\u7528\u30ea\u30b9\u30af\u4f4e\u6e1b\u306e\u53ef\u80fd\u6027\u3042\u308a\u3002<\/li>\n\n\n\n<li>1 mg\u306f\u6d77\u5916\u6a19\u6e96\u7528\u91cf\u3067\u3042\u308a\u3001\u56fd\u969b\u7684\u5b89\u5168\u6027\u30c7\u30fc\u30bf\u306e\u53c2\u7167\u3084\u56fd\u969b\u6574\u5408\u6027\u306e\u78ba\u4fdd\u306b\u5fc5\u9808\u3002<\/li>\n\n\n\n<li>\u81e8\u5e8a\u73fe\u5834\u3067\u306e\u7528\u91cf\u9078\u629e\u80a2\u3092\u6b8b\u3059\u3053\u3068\u3067\u3001\u60a3\u8005\u7279\u6027\u3084\u526f\u4f5c\u7528\u6b74\u306b\u5fdc\u3058\u305f\u67d4\u8edf\u306a\u6295\u4e0e\u304c\u53ef\u80fd\u306b\u306a\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u627f\u8a8d\u65e5:<\/strong> 2005\u5e7410\u670811\u65e5\uff08\u30d7\u30ed\u30da\u30b7\u30a20.2 mg\u9320\u30011 mg\u9320\uff09<br><strong>\u8ca9\u58f2\u958b\u59cb:<\/strong> \u540c\u5e7412\u670814\u65e5<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">5. \u627f\u8a8d\u5f8c\u306e\u5e02\u5834\u52d5\u5411<\/h3>\n\n\n\n<p>\u627f\u8a8d\u5f53\u521d\u306f\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u526f\u4f5c\u7528\u61f8\u5ff5\u304c\u3042\u308b\u60a3\u8005 \u2192 0.2 mg<\/li>\n\n\n\n<li>\u6a19\u6e96\u6cbb\u7642 \u2192 1 mg<br>\u3068\u3044\u3046\u4f7f\u3044\u5206\u3051\u304c\u60f3\u5b9a\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u3057\u304b\u3057\u3001\u5b9f\u969b\u306e\u51e6\u65b9\u52d5\u5411\u306f\u6025\u901f\u306b1 mg\u306b\u96c6\u7d04\u3055\u308c\u307e\u3059\u3002\u7406\u7531\u306f\u4ee5\u4e0b\u306e\u901a\u308a\uff1a<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>\u56fd\u969b\u6a19\u6e96\u304c1 mg<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u6d77\u5916\u8ad6\u6587\u3084\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u304c\u3059\u3079\u30661 mg\u57fa\u6e96\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u526f\u4f5c\u7528\u5dee\u304c\u5c0f\u3055\u3044<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u56fd\u5185\u6cbb\u9a13\u3067\u3082\u6027\u6a5f\u80fd\u526f\u4f5c\u7528\u5dee\u306f\u7d041.4\u30dd\u30a4\u30f3\u30c8\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u85ac\u4fa1\u5dee\u304c\u5c0f\u3055\u3044<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u8cbb\u7528\u9762\u30670.2 mg\u3092\u9078\u629e\u3059\u308b\u30e1\u30ea\u30c3\u30c8\u304c\u4e4f\u3057\u3044\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30b8\u30a7\u30cd\u30ea\u30c3\u30af\u666e\u53ca\u5f8c\u3082\u50be\u5411\u5909\u308f\u3089\u305a<\/strong>\n<ul class=\"wp-block-list\">\n<li>2015\u5e74\u4ee5\u964d\u3001\u30b8\u30a7\u30cd\u30ea\u30c3\u30af\u767b\u5834\u306b\u3088\u308a\u85ac\u4fa1\u5dee\u304c\u7e2e\u5c0f\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n\n\n\n<p>\u73fe\u5728\u306e\u5e02\u5834\u30b7\u30a7\u30a2\u306f\u63a8\u5b9a\u3067<strong>1 mg\u304c9\u5272\u8d85\u30010.2 mg\u306f\u307b\u307c\u9650\u5b9a\u51e6\u65b9<\/strong>\u3068\u307f\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">6. \u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306e\u5909\u9077<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>2005\u5e74\uff08\u627f\u8a8d\u76f4\u5f8c\uff09:<\/strong> \u65e5\u672c\u76ae\u819a\u79d1\u5b66\u4f1aAGA\u8a3a\u7642\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u306f\u30010.2 mg\u30fb1 mg\u3068\u3082\u63a8\u5968\u5ea6A\u3002<\/li>\n\n\n\n<li><strong>2017\u5e74\u6539\u8a02:<\/strong> \u5b9f\u81e8\u5e8a\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u84c4\u7a4d\u306b\u57fa\u3065\u304d\u3001\u8a18\u8f09\u306f1 mg\u4e2d\u5fc3\u306b\u30020.2 mg\u306f\u88dc\u8db3\u7684\u6271\u3044\u306b\u79fb\u884c\u3002<\/li>\n\n\n\n<li><strong>\u6d77\u5916\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3:<\/strong> \u7c73\u56fd\u76ae\u819a\u79d1\u5b66\u4f1a\u30fb\u6b27\u5dde\u76ae\u819a\u79d1\u5b66\u4f1a\u3044\u305a\u308c\u30821 mg\u3092\u6a19\u6e96\u63a8\u5968\u7528\u91cf\u3068\u8a18\u8f09\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">7. \u73fe\u72b6\u306e\u81e8\u5e8a\u7684\u4f4d\u7f6e\u3065\u3051<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>0.2 mg\u306f\u3001\u6027\u6a5f\u80fd\u526f\u4f5c\u7528\u3092\u5f37\u304f\u61f8\u5ff5\u3059\u308b\u60a3\u8005\u3084\u9ad8\u9f62\u8005\u306b\u304a\u3051\u308b\u521d\u671f\u6295\u4e0e\u7528\u3068\u3057\u3066\u3001\u307e\u308c\u306b\u4f7f\u7528\u3055\u308c\u308b\u7a0b\u5ea6\u3002<\/li>\n\n\n\n<li>1 mg\u304c\u4f9d\u7136\u3068\u3057\u3066\u7b2c\u4e00\u9078\u629e\u3002<\/li>\n\n\n\n<li>\u30c7\u30e5\u30bf\u30b9\u30c6\u30ea\u30c9\uff080.5 mg\uff09\u306e\u767b\u5834\u306b\u3088\u308a\u3001\u9032\u884c\u4f8b\u3084\u52b9\u679c\u4e0d\u5341\u5206\u4f8b\u3067\u306f\u5207\u308a\u66ff\u3048\u304c\u884c\u308f\u308c\u308b\u30b1\u30fc\u30b9\u3082\u5897\u52a0\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">8. \u5c06\u6765\u5c55\u671b<\/h3>\n\n\n\n<p>\u8fd1\u5e74\u3001\u6d77\u5916\u3067\u306f<strong>\u4f4e\u7528\u91cf\u30d5\u30a3\u30ca\u30b9\u30c6\u30ea\u30c9\uff080.25\u301c0.5 mg\uff09\u3067\u3082\u4e00\u5b9a\u52b9\u679c\u304c\u5f97\u3089\u308c\u308b\u53ef\u80fd\u6027<\/strong>\u3092\u793a\u3059\u5831\u544a\u304c\u3042\u308a\u3001\u526f\u4f5c\u7528\u4f4e\u6e1b\u3068\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u518d\u8a55\u4fa1\u3059\u308b\u52d5\u304d\u304c\u3042\u308a\u307e\u3059\u3002<br>\u305f\u3060\u3057\u3001\u3053\u308c\u3089\u306f\u77ed\u671f\u8a66\u9a13\u304c\u591a\u304f\u3001\u9577\u671f\u5b89\u5168\u6027\u3084\u52b9\u679c\u6301\u7d9a\u6027\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u4e0d\u8db3\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u65e5\u672c\u3067\u3082\u4eca\u5f8c\u3001\u60a3\u8005\u5c64\u3084\u526f\u4f5c\u7528\u30ea\u30b9\u30af\u306b\u5fdc\u3058\u305f<strong>\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u7528\u91cf\u9078\u629e<\/strong>\u304c\u518d\u3073\u8b70\u8ad6\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">\u307e\u3068\u3081<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30d5\u30a3\u30ca\u30b9\u30c6\u30ea\u30c9\u306f1997\u5e74\u306b\u7c73\u56fdFDA\u304c1 mg\u3092AGA\u6cbb\u7642\u85ac\u3068\u3057\u3066\u627f\u8a8d\u3001\u65e5\u672c\u3067\u306f2005\u5e74\u306b0.2 mg\u30681 mg\u304c\u540c\u6642\u627f\u8a8d\u3055\u308c\u305f\u3002<\/li>\n\n\n\n<li>0.2 mg\u627f\u8a8d\u306f\u3001\u4f4e\u7528\u91cf\u306e\u5b89\u5168\u6027\u30fb\u9078\u629e\u80a2\u78ba\u4fdd\u30fb\u56fd\u969b\u6574\u5408\u6027\u306e\u305f\u3081\u3060\u3063\u305f\u304c\u3001\u5b9f\u969b\u306e\u5e02\u5834\u3067\u306f\u307b\u307c1 mg\u306b\u96c6\u7d04\u3002<\/li>\n\n\n\n<li>\u73fe\u5728\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u30821 mg\u3092\u6a19\u6e96\u3068\u3057\u30010.2 mg\u306f\u9650\u5b9a\u7684\u306a\u4f4d\u7f6e\u3065\u3051\u3002<\/li>\n\n\n\n<li>\u5c06\u6765\u7684\u306b\u306f\u3001\u526f\u4f5c\u7528\u3068\u52b9\u679c\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u8003\u616e\u3057\u305f\u4f4e\u7528\u91cf\u6226\u7565\u304c\u518d\u8a55\u4fa1\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u2014 FDA\u627f\u8a8d\u304b\u3089\u539a\u52b4\u7701\u627f\u8a8d\u3001\u5e02\u5834\u6dd8\u6c70\u307e\u3067\u306e\u5168\u8c8c \u2014 1. \u30d5\u30a3\u30ca\u30b9\u30c6\u30ea\u30c9\u3068\u306f 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